Competition funded PhD in Aerosolised Layered double hydroxides (LDHs) for lung drug deliver

Layered double hydroxides (LDHs) are tuneable two-dimensional nanomaterials with demonstrated promise as platforms for the delivery of biological molecules via aerosol formulations. Their unique material properties—namely, adjustable particle size, plate-like morphology, and surface charge—enable enhanced penetration through biological barriers, optimised uptake by target cells, and control over release kinetics. In aerosol science, such material characteristics are critical for influencing deposition patterns, tissue targeting, and immunostimulatory effects, which pave the way for targeted drug and vaccine delivery directly to the respiratory system.

Recent advances in synthesising LDHs with controlled physical and chemical parameters have led to their emergence as leading candidates for pulmonary drug delivery and vaccine effect. However, a systematic study is required to relate their specific material properties to in-aerosol formulation behaviour, stability, and in vivo delivery efficiency. This project addresses this need, leveraging the multidisciplinary expertise of Imperial College and Iuvantium’s platform for the application of inorganic nanomaterials in immunobiological applications.

The PhD candidate will synthesise libraries of LDH nanoparticles with systematically varied sizes, morphologies, and surface charges using advanced wet-chemical methods. Comprehensive physicochemical characterisation will be conducted (SEM, DLS, zeta potential analysis, fluorescence spectroscopy) to correlate particle traits with in vitro and in aerosol behaviour.

Candidates who aspire to work in a multidisciplinary field, and hold or will achieve a minimum of an upper second-class undergraduate degree in any of these areas are encouraged to apply: chemistry, physics, biological sciences, life and medical sciences, mathematics and computer science, chemical and mechanical engineering, pharmaceutical and environmental sciences.